[Music]
hi great to be here uh just first a
brief intro to myself
um I'm a hard tech Pioneer in moonshots
I've created multiple multi-billion
dollar products on the hay edge of
physics former MIT professor Brown
University PhD in physics and about
eight years ago I started my latest
project it's called open water and in
rooms like these we've been building
trying to look at this idea of using the
fact that our
bodies can be penetrated by infrared
light ultrasound and
electromagnetics and a belief that maybe
we could Leap Frog current Health Care
Systems and even drugs by modulating the
phase of light and
sound so we've been doing that for a
while um and and the reason that I did
it is I've shipped a lot of innovative
silicon ships so using silicon
manufacturing that's coming online and
consumer electronics and phase
wve
steering I knew that we could steer
beams of light decode phase with
interference and even selectively
select uh or destroy certain cells or
stimulate certain cells so we built
these systems up for about four years
got pretty interesting results filed a
bunch of patents a lot of work and
decided in early 2020 to get them in a
hospitals start testing this on people
and the results are somewhat spectacular
first in stroke large vessel occlusion
stroke is the number two killer in the
world if you could diagnose that stroke
in an ambulance you could get the
patient to the one of less than 5% of
hospitals that could treat that stroke
so the person Wouldn't Die so we built a
portable that gives higher specificity
and sensitivity for large vegetable
collusion stroke than we can find
published anywhere in the world that's
6.5 Million Lives per year now we go
over to number three uh
gleo we uh gave some mice gleo blastoma
and treated them and moved these mice
into Mission and on
autopsy uh found that we didn't harm any
healthy cells Charles River couldn't
find any while we were waiting to get
into humans for that we take that same
device and put it into humans for severe
depression and a 20 person trial and we
were able to turn off the overfiring
neurons in the default mode Network
sending these patients into
remission so with that we're pretty
excited
it was time to go get more money we've
raised $100 million today and we're
announcing today for the first time that
falic gave us $50 million from the Shibu
enu coin woohoo thank you non- delative
and it made it's made all the difference
with that
money we've been able to reduce those
carts from really a laser the size of a
room to
this that's going into production next
month and those carts that were the size
of the size of the rim as well to these
to little consoles and all of that's
going into
production next month this is a platform
with a life-saving pan disease potential
for not just stroke but all
cardiovascular disease not just gleo
blastoma but all cancers not just mental
disease but potentially all mental
disease and
Beyond so open source is cool we're all
believers but where this impacts the
health care is even if you make hardware
and software open source we open sourced
all of our
patents you still need approval to use
it on
somebody it's FDA it's regulatory
approval the reality is in a
comprehensive paper published recently
the average cost of a novel therapeutic
medical device approval is now $658
million in capitalized cost in 13 years
so even if you open source it huh what
do you do well the key is here 85% of
that cost isn't in clinical trials it's
in the
device so that takes a lot out further
another 7% of that is in safety so share
the safety do we want a safer device or
a less safe device will the regular Ator
be able to approve a device pan cancer
disease with lots with a 100 times more
safety data will that make a choice
easier or not will a doctor and patient
find it easier to be able to access the
safety data we think it's yes on all of
those running those numbers our
hypothesis is we take $653 million out
of the cost of developing a novel
medical device with a denovo approval so
down to 5 million sub three years
so how does this work phase wave
modulation well these are the waves in
light and sound and what we do for
example on these yellow emitters is we
delay the phase from emitter to emitter
so we can focus that sound near or far
right or left up or down anywhere we
wish to in the brain or the body so gleo
blastoma cells can hide out among
healthy neurons and the neurosurgeon you
know they can't take a
small but these cells have a mechanical
property that no other cells do all
aggressive cancer cells have really
large nucleuses and small
cytoplasms and we can exploit that like
an opera singer can ping this wine glass
hit that note and destroy that wine
glass and harm nothing else in the room
so that's what we're doing with gleo
blastoma we did sonification parameter
sweeps found frequencies this is low
intensity ultrasound lower intensity
than used for Diagnostic reasons on
pregnant women and their fetuses for the
last 50 years in rich countries but
these cells can't take it we're
destroying
them and here at a different frequency I
can tell you the frequency of Ro this is
400 khz the other one is 150
khz we're able to turn on stimulate or
um Des stimulate uh neurons and that's
been helpful not just for non-invasive
brain computer interface but also for
pulling people out of mental disease
addictions and so forth It's all
together I
think we're enabling read WR brain
computer interface while we're trying to
solve mental diseases it's they're
impossible to
separate so another module this is our
read module uses that laser I just
picked up that we've reduced down this
laser and a bunch of camera chips four
camera chips that are in your smartphone
and those camera chips are super small
we take the lens off and they've got
they're cheap because they're small they
have pixel sizes the size of the
wavelength of light so we let that light
go into oh that didn't fly okay we'll
let that light go into the head and what
we see on that camera chip is this and
it looks like the waves on the ocean and
we can read the waves on the ocean like
a sailor can read the waves on the ocean
and know where the fish are know where
the land is here
we interrogate a blood vessel and the
pattern changes because where the light
hits the moving blood cells it Ricochet
is differently changing that pattern and
we we can read blood flow very
accurately with this way in fact we can
read it 20 times more accurately by some
measures than multi-million dollar MRI
or CT scanners with this laser and some
camera chips so that's not just good for
stroke but all cardiovascular disease
and all Micro Motions of the body we
believe so to get this far we've been
working with a whole bunch of great
institutes but everybody wants it so
that's why we Shrunk the system down and
decided to go into production and also
you you can build it it's all on GitHub
you can build it yourself if you'd like
to everyone that wants it you can all
have it you don't need permission go to
our web website take it um I want to
mention here there's also evidence we
may be able to suppress cyto storms as
Amy just discussed the impact of them
treat inflammation even deactivate covid
with the same way we're
deactivating Leo blastoma cells there's
some evidence we're working on that in
our labs and we're using our devices to
do research on long covid and microclots
we can see if we can ID them and if we
can break them apart so as we
discussed this is the problem $658
million in 13 years it's why we don't
get any new devices it's why healthare
we've got 20 to 40 year Innovation modes
so here's what we're doing about it
we're flipping it on the side to make a
open- source General general purpose
platform and the apps on top of these
are the treatments so those are the ones
with regulatory approval 3 years $5
million then we get into they call it a
510k substantial equivalence sub $1
million sub one
year so the question we're for-profit
company I'm just I hate to be crash but
people are sort of scratch their heads
and ask me quietly afterwards and so I
thought i' just come out like look it's
free as in beer free as in speech not
free as in beer like you can publish the
recipe of the beer you can go make your
own at home most of us just go to the
store to buy it but by making more of
something it's cheaper we enjoy a
portion of that savings as
profit we engender trust that's new we
don't charge $1,400 for an EpiPen one
day if we miss step on something if we
screw up you can go get it made yourself
but we ensure quality standard that's
IRB ready and FDA ready we ISO 1345
compatible by safety sharing we have the
cost of clinical trials and double the
speed for our customers plus everybody
just benefits that's a cycle of
innovation that's not a 20-year
moat so here are these new units I've
got them out here Liu and open motion
all the electronics are going into the
Mechanicals and being tested so they'll
be ready next month here's more and this
brings me to a moment we also did
something uh just to save another
$50,000 using our smartphone and
metallic are you going to come up to get
scanned in so this is just
in so we prepped a little on this so
this is the whole unit that's replacing
that room and so if we put this on
you
ah I can actually turn it
on see it so and then I
will oops the strapping is being
perfected it's velcro I don't think it's
sticky enough can you all right so what
we do
oops thank you for doing
this um oops I just open the wrong
nap so I'm just putting in a number here
and then I
start and
uh I was just saying unable to focus
okay try again
okay
um
okay so I'm just taking some pictures of
him with the
camera that's all you have to do is walk
around and then we have to get the top
of his
head
okay that's it so that's all um so we
can take this off now although we should
leave it on if we were actually going to
uh sonicate him so
now we scan him
in and
falic has an amazing brain and we get to
look at it right here although this
isn't the interesting part of it this is
an MRI he did last week and what we're
going to do is pick a
spot for a Target the anterior singlet
it's going to make him
happy we know that and so okay we
scanned him so these are what the
pictures look like and then this is
making him
3D and this is so we can know where the
the I'll show you what this is does so
here we overlay the 3D MRI with a scan
so we match his bone
structure and then we look at where the
transducers are and we know exactly
where they are and now we sit the Target
and we compute what phase delays we need
on the
transducers and then we nail that Target
I would love to sonicate him on stage
but we don't have permission from the
Thai government yet
however I met somebody that got
permission to do 200 people at eselon
recently so next year we'll do something
but yeah this is how it works for any
part in your body and the interesting
part is as we develop our read part the
part seing blood flow we can get away
from the MRI machine and use different
scanning technology that's lower
cost so with that this is somewhat like
a smartphone moment from 20 years ago
smartphones changed our lives look a
silicon Hospital can happen if you think
of your smartphone there's a dozen
radios in it four cameras and so forth
as we populate this it can treat us for
the diseases we have again you might be
asking can I have one my company what
com country whatever yes everybody can
have one everyone has permission you can
build your own I'll be showing these
types out in the hall shortly and thank
[Applause]
you thank you