[Music]
take it
away hi my name is Nathan Chang and I'll
be talking about the longevity
acceleration road map a technical plan
to solve
aging this road map is a foundational
project at the lbf and it's intended to
help guide newcomers to longevity space
I can only do a speedrun now but if
you're interested in the full thing
check out the link below okay so the lbf
is a nonprofit that I co-founded to
mobilize the world's top talent to work
on solving
aging but why work on Aging uh well
simply because life is good and death is
bad and if you ask what is the thing
that causes the most death uh it's aging
so by far aging causes the most death
75% of deaths worldwide are caused by
aging and this comes in the form of age
related diseases like heart disease
cancers Alzheimer's Etc and this is an
emergency uh all 8 billion humans are on
a exponential trajectory towards
physical and cognitive decline and
ultimately
death but if we can solve aging we can
Envision a future where people can live
for as long as they want in Peak health
and
function but if you want to see this
future uh like personally uh we we need
to do something about aging today so
where's the plan to solve aging well
when we first started we couldn't find
any clear plan to solve aging uh so we
had to make one on our own and in our
plan we wanted to uh have three key
features so one uh we wanted to
exclusively focus on Direct research and
Technology paths that could solve aging
completely and uh two um we wanted to uh
focus on specific welldefined key
technical objectives and three um we
wanted it to be actionable so um have a
good overview of projects in the space
so that people could easily uh join or
start them or or fund them okay so we
got a lot of input from uh scientists
researchers and entrepreneurs in the
field and uh we identified three main
strategies that could posibly uh self
aging so one is biostasis this means uh
pausing biological time and this is
typically with uh cryopreservation at
low temperature or chemical fixation uh
two uh replacement so replacing old
Parts with young um and most promising
full body uh transplants less gradual
brain replacement and three Advanced
bioengineering so understanding and
modeling biology and aging um and also
developing genetic and cellular uh
engineering
tools okay so one mental model to kind
of understand these three technology
paths is a 2 by two Matrix so in one
axis you're trying to solve aging uh or
or by time and the other axis you're
either trying to um understand aging or
or uh bypass aging like the complexity
of Aging altogether and just as a side
note um some of these Technologies can
also be thought of General defensive
biomedical Technologies so um for for
example in like uh replacement um could
be useful for things Beyond aging so if
you got in a car accident replacement
could be life- saving okay so let's take
a look at biostat this um so the
strategy here is to pause biological
time until the future where uh medical
Technologies can solve aging
um but uh you know there's a number of
key objectives in the spread map I can't
go over all of them so I'll just
highlight one of them so um rapid even
rewarming so this is needed to uh
prevent ice formation and and the Damage
associated with that but also to um
prevent uh thermal fracturing so when
you're uh trying to bring a body or or
brain from low temperature back to to
room temperature so there's a number of
different projects and startups in the
space but there uh still needs to a lot
of to be done okay let's talk about
replacement so um this strategy is
divided into two parts so there's
replacing the body with a clone body and
uh knockout of the brain but then two
for the brain uh you gradually replace
the brain um with young neural tissue
graphs bit by bit kind of like in the
style of the ship
Aus now in the body um this really uh
has only become Within Reach uh since
2018 when uh Chinese scientists
demonstrated the first successful
cloning of primates and uh it's
plausible that this could be extended to
humans okay but uh you can create a
clone body but you you don't want to
create a brain at the same time a person
so you'll need to construct a a a
genetic construct to ensure that that
the capacity uh to have Consciousness uh
never forms in the cloned embryo and
there's actually already a natural proof
of concept uh for this it's the birth
defect called Hydra and inphy uh where
cerebral hemispheres uh never form and
uh these bodies actually never have
Consciousness but uh can develop to full
maturity and last uh to put it together
you have have to do some sort of uh head
transplant and uh these have been done
experimentally in the past uh in mice
dogs and monkeys um with survival in
some cases lasting days to to months but
still needs to be improved okay so um
let's move on to the brain uh as I said
before you can gradually replace the
brain with uh engineered neural neural
tissue graphs made from a patient's own
ipsc stem cells and um neuroplasticity
of the brain allows migration of brain
functions away from damaged areas or or
um if done uh slowly and just recently
the US rph program uh hired the leading
researcher in brain replacement Jean
habber to lead a $100 million Moon shot
program in this
strategy there's um a number of uh key
technical objectives in our V1 road map
uh most of the hard stuff is in the
brain but also in spinal uh cord
reconnection and there's a number of
startups working in this field but uh
most are still in
stealth okay uh we also asked
researchers to estimate the time and
cost to um get a reasonable attempt on
this on this road map and uh they came
up with a a figure of $3.6 billion and
and about 10 years hey last
bioengineering um so this is the uh
longest the most uncertain Road it will
require the convergence of four um four
different prongs so one large scale data
collection um something like a protein
Data Bank but but much larger scale um
two um computational modeling uh which
could include AI models and then three
uh design of genetic or cellular
interventions and four uh delivery of
genetic uh interventions or or cell
cells okay next steps so clearly there's
a lot of work to be in uh to solve aging
but unfortunately there's very few
people or resources trying to um uh
devoted to trying to solve aging um so
if you feel an intense desire to defeat
aging uh definitely join the lbf we're
the biggest Community focused
exclusively on building for indefinite
lifespan extension um we run uh highly
selective intensive Workshop Retreats
our next one is in March in Berkeley
California and um but uh fighting aging
is not just for biotechs and scientists
um we need everyone to get uh Society
aligned on allocating Apollo program
level resources to fighting aging and so
if this resonates with you I'd encourage
you to also join the vitalism community
where we're building a social political
movement uh to make fighting aging and
death Humanities number one priority um
and uh our community is organizing the
biggest longevity event in the world
it's going to be um a two-month uh
pop-up longevity City in Berkeley
California